Cognitive decline is a major concern of the aging population, and Alzheimer’s disease is the major cause of age-related cognitive decline, with approximately 5.4 million American patients and 30 million affected globally. In the absence of effective prevention and treatment, the prospects for the future are of great concern, with 13 million Americans and 160 million globally projected for 2050, leading to potential bankruptcy of the Medicare system. Unlike several other chronic illnesses, Alzheimer’s disease prevalence is on the rise, which makes the need to develop effective prevention and treatment increasingly pressing. Recent estimates suggest that AD has become the third leading cause of death in the United States , behind cardiovascular disease and cancer. Furthermore, it has been pointed out recently that women are at the epicenter of the Alzheimer’s epidemic, with 65% of patients and 60% of caregivers being women . Indeed, a woman’s chance of developing AD is now greater than her chance of developing breast cancer .